![\"P\u00edldora\"](\"http:\/\/iguala3.org\/wp-content\/uploads\/2018\/09\/farmaco-experimental-300x205.jpg\")
<\/a>Investigadores del CIBER de Bioingenier\u00eda, Biomateriales\u00a0<\/b>y\u00a0Nanomedicina<\/b>\u00a0(CIBER-BBN) en el Instituto de Investigaci\u00f3n Biom\u00e9dica de Sant Pau (IIB Sant Pau), la Universitat Aut\u00f2noma de Barcelona (UAB) y el CSIC han demostrado en un modelo animal la eficacia de un nanof\u00e1rmaco, creado por los propios investigadores, que elimina selectivamente las c\u00e9lulas madre metast\u00e1sicas en modelos animales de c\u00e1ncer de colon.<\/p>\nEl nuevo f\u00e1rmaco funciona como un dron que identifica las c\u00e9lulas madre metast\u00e1sicas, administra el f\u00e1rmaco y destruye \u00fanicamente estas c\u00e9lulas bloqueando la met\u00e1stasis. De esta forma se evita la toxicidad general asociada a los tratamientos habituales, y se abre una nueva v\u00eda para prevenir la met\u00e1stasis en el c\u00e1ncer colorrectal.<\/p>\n
Se trata del primer f\u00e1rmaco en el mundo que bloquea la diseminaci\u00f3n metast\u00e1sica, la principal causa de muerte en pacientes oncol\u00f3gicos. Actualmente, no existen f\u00e1rmacos en el mercado que eliminen selectivamente las c\u00e9lulas madre metast\u00e1sicas. Por lo tanto, este nuevo descubrimiento podr\u00eda tener un alto impacto cl\u00ednico despu\u00e9s de que se hayan realizado los ensayos necesarios para aplicarse en humanos.<\/p>\n
El estudio, que ha sido publicados en \u2018EMBO Molecular Medicine\u2019, ha sido liderado por Ram\u00f3n Mangues, del IIB Sant Pau, Antonio Villaverde y Esther V\u00e1zquez, de la UAB, y todos ellos miembros del CIBER-BBN. Los investigadores han demostrado que el f\u00e1rmaco act\u00faa solamente sobre las c\u00e9lulas iniciadoras de met\u00e1stasis a trav\u00e9s de su interacci\u00f3n espec\u00edfica entre un p\u00e9ptido presente en la nanopart\u00edcula proteica que lo transporta y el receptor celular CXCR4 que se encuentra sobreexpresado en las c\u00e9lulas tumorales.<\/p>\n
Esto permite atacar solamente a las c\u00e9lulas tumorales, bloqueando su diseminaci\u00f3n en estadios tempranos, de manera que previene la aparici\u00f3n de met\u00e1stasis a la vez que evita los efectos adversos derivados de los tratamientos habituales. \u201cSe ha observado que este receptor est\u00e1 sobreexpresado en 20 tipos diferentes de c\u00e1ncer como m\u00ednimo, entre ellos los de pr\u00f3stata, mama, ovario y otros no tan comunes como el de p\u00e1ncreas.<\/p>\n
Lo que significa que esta nanopart\u00edcula se puede dirigir para tratar diferentes tipos de neoplasias, convirti\u00e9ndola en un veh\u00edculo muy vers\u00e1til que puede transportar diferentes mol\u00e9culas terap\u00e9uticas de elevada potencia\u201d, a\u00f1aden los investigadores. El Hospital de Sant Pau de Barcelona ser\u00eda el primer centro en el mundo en evaluar este f\u00e1rmaco en humanos, previamente a su posible introducci\u00f3n en la terap\u00e9utica cl\u00ednica.<\/p>\n
En junio de 2017 los investigadores del CIBER-BBN, el IIB Sant Pau y el Instituto de Biotecnolog\u00eda y Biomedicina de la UAB que firman ahora el art\u00edculo de EMBO Molecular Medicine pusieron en marcha Nanoligent, una spin-off creada para desarrollar el primer f\u00e1rmaco dise\u00f1ado para eliminar las c\u00e9lulas metast\u00e1sicas.<\/p>\n
Esta empresa, que tiene m\u00e1s de 10 a\u00f1os de estudios a sus espaldas, est\u00e1 dirigida por Manuel Rodr\u00edguez Mariscal, profesional con una larga experiencia en el campo de la inversi\u00f3n y la creaci\u00f3n de compa\u00f1\u00edas biotecnol\u00f3gicas y tiene como objetivo conseguir la financiaci\u00f3n para la realizaci\u00f3n del proyecto.<\/p>\n
Fuente:<\/em>\u00a0www.lavanguardia.com<\/p>\n","protected":false},"excerpt":{"rendered":"Se trata de un nanof\u00e1rmaco que abre una nueva v\u00eda para la prevenci\u00f3n de la met\u00e1stasis en el c\u00e1ncer colorrectal. Investigadores del CIBER de Bioingenier\u00eda, Biomateriales\u00a0y\u00a0Nanomedicina\u00a0(CIBER-BBN) en el Instituto de Investigaci\u00f3n Biom\u00e9dica de Sant Pau (IIB Sant Pau), la Universitat Aut\u00f2noma de Barcelona (UAB) y el CSIC han demostrado en un modelo […]<\/p>\n","protected":false},"author":1,"featured_media":1111,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[38,36,37],"class_list":{"0":"post-1110","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-noticias","8":"tag-cancer","9":"tag-farmaco","10":"tag-metastasis","11":"czr-hentry"},"yoast_head":"\n
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![\"P\u00edldora\"](\"http:\/\/iguala3.org\/wp-content\/uploads\/2018\/09\/farmaco-experimental.jpg\")
<\/a>Investigadores del CIBER de Bioingenier\u00eda, Biomateriales\u00a0<\/b>y\u00a0Nanomedicina<\/b>\u00a0(CIBER-BBN) en el Instituto de Investigaci\u00f3n Biom\u00e9dica de Sant Pau (IIB Sant Pau), la Universitat Aut\u00f2noma de Barcelona (UAB) y el CSIC han demostrado en un modelo animal la eficacia de un nanof\u00e1rmaco, creado por los propios investigadores, que elimina selectivamente las c\u00e9lulas madre metast\u00e1sicas en modelos animales de c\u00e1ncer de colon.<\/p>\n